Francisco Rafael Martins Laurindo and Luis Eduardo Soares Netto, scientists from the Research Center for Redox Processes in Biomedicine - RIDC Redoxoma, have been elected full members of the São Paulo State Academy of Sciences (ACIESP). The recognition highlights their pioneering contributions to redox biology and health.

Trained as a physician at the University of São Paulo School of Medicine, Laurindo is Director of the Vascular Biology Laboratory at the InCor and Deputy Director of Redoxoma. His research has shed light on redox signaling mechanisms in the vascular system, focusing on the mechanisms and regulatory pathways that govern the production of oxidant species in vascular cells and tissues, and how these processes impact vessel remodeling in cardiovascular disease.

Among his most notable contributions are the demonstration of superoxide generation by the endothelium under shear stress and the characterization of the functional interaction between protein disulfide isomerase (PDI) and NADPH oxidase complexes. More recently, Laurindo’s research uncovered an important role for extracellular PDI in arterial remodeling after injury, further expanding the understanding of how redox-dependent mechanisms orchestrate vascular adaptation in health and disease.

Luis Netto is a professor at the Institute of Biosciences at the University of São Paulo (IB-USP) and a member of the Redoxoma steering committee. He is a specialist in cellular defense mechanisms against free radicals and reactive species, with emphasis on peroxiredoxins and other thiol-based proteins. He obtained his PhD under the supervision of Professor Ohara Augusto and conducted postdoctoral research at the NIH (USA), where he contributed to demonstrating the enzymatic activity of peroxiredoxins, antioxidant proteins central to the metabolism of hydrogen peroxide and other peroxides.

His research has revealed, among other advances, the reduction of 1-Cys peroxiredoxins by vitamin C and the role of Ohr enzymes in the resistance of pathogenic bacteria to oxidative stress.

The newly elected members join ACIESP alongside other Redoxoma researchers already recognized by the Academy, such as Ohara Augusto, Alicia Kowaltowski, Maurício Baptista, Paolo Di Mascio, and Marisa Medeiros, thus reinforcing the Center’s tradition of excellence.